微生理系统 (MPS) 在与衰老相关的和老年疾病研究中的最新发展:一篇综述
Chao Song1, Jiachen Yang1, Zhongze Gu1
1State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China; School of Biological Science & Medical Engineering, Southeast University, Nanjing, China.
Ageing research reviews
|March 9, 2025
概括
微生理系统 (MPS) 为研究衰老和相关疾病提供先进的仿生模型. 这些芯片上的器官和器官平台改善了疾病建模,药物查和对衰老机制的理解.
科学领域:
- 生物医学工程 生物医学工程
- 老年学是一门学科.
- 组织工程是组织工程.
背景情况:
- 老龄化导致组织功能障碍和老年疾病的风险增加,由全球老龄化趋势和流行病加剧.
- 目前的体外和体外模型在准确模拟人类衰老和疾病方面存在局限性.
- 微生理系统 (MPS) 利用微流体和组织工程来创建生物模拟环境来研究衰老.
研究的目的:
- 审查MPS的最新进展,以建模与年龄相关的和老年疾病.
- 突出在衰老研究中的有机体和器官芯片技术的应用.
- 为使用MPS探索疾病机制,治疗和药物查提供指导方针和示例.
主要方法:
- 关于用于衰老研究的微生理系统 (MPS) 的最新文献的审查.
- 专注于有机体和芯片器官技术.
- 分析MPS在特定年龄相关疾病建模中的应用.
主要成果:
- 包括有机体和芯片上的器官在内的MPS为模拟人类组织微环境提供了增强的仿生模型.
- 这些系统在研究心血管,脑血管,神经退行性,纤维性和退行性疾病方面表现有前途.
- MPS的应用扩展到了解罕见疾病和改善临床试验的可预测性.
结论:
- 对于研究衰老和相关疾病的传统模型来说,MPS是一个显著的进步.
- 未来的方向包括跨学科的方法来解决局限性,并提高MPS在衰老研究的潜力.
- MPS为探索疾病病理生理学,促进药物发现和老年病学个性化医学提供了改进的平台.
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