相关实验视频
Updated: May 23, 2025

06:09
An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
9.8K
探索各种治疗精油与雷帕格林尼德协同作用的抗糖尿病作用
Omnia M Sarhan1, Samaa O Abdelqader1, Mostafa S A Mostafa2
1Department of Pharmaceutics, Faculty of Pharmacy, Badr University in Cairo, Cairo 11829, Egypt.
Journal of pharmaceutical sciences
|March 9, 2025
概括
红油微乳液在治疗糖尿病方面表现有前途,与标准治疗相比,提供了改善的Repaglinide输送和更好的治疗结果. 这些配方增强了药物的生物可用性,并为有效的抗糖尿病治疗提供持续释放.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 糖尿病仍然是一个重大的全球健康挑战,需要创新的治疗策略.
- 雷帕格林是一种口服抗糖尿病药物,但其输送可以优化以提高疗效.
- 微乳液为改善药物的溶解性和生物可用性提供了一个多功能平台.
研究的目的:
- 使用红油,黑油和橄油制备和表征稳定的微乳液.
- 评估这些微乳液作为repaglinide药物输送系统的潜力.
- 在体内评估优化微乳液配方的抗糖尿病疗效.
主要方法:
- 使用相位图来确定最佳的微乳液成分 (油,水,表面活性剂,共同表面活性剂).
- 配方通过传输电子显微镜对液滴大小,泽塔潜力和形态学进行了特征化.
- 进行了体外药物释放研究 (透析方法) 和体内抗糖尿病疗效研究.
主要成果:
- 成功制备了具有最佳物理化学性质 (粒子大小,泽塔潜力,球形形态) 的稳定微乳液.
- 与其他油性配方相比,红油微乳液表现出更好的持续和受控释放的雷帕格林化物.
- 在体内研究表明,使用红油微乳液显著改善了抗糖尿病结果,这归因于提高生物可用性.
结论:
- 基于红油的微乳液是一种有前途的先进药物输送系统,用于Repaglinide.
- 这些配方具有卓越的物理化学和控制释放特性,为改善糖尿病管理提供了潜力.
- 该研究强调了糖尿病的创新治疗方案,为患者带来了更好的治疗效益.
相关概念视频
Oral Hypoglycemic Agents: Glinides
127
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
127
Dipeptidyl Peptidase 4 Inhibitors
155
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
155
Oral Hypoglycemic Agents: Biguanides and Glitazones
149
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
149
Glucagon-like Receptor Agonists
289
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
289
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
141
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
141
Insulin: Dosing Regimen and Adverse Effects
136
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
136

