[在患有MASLD和MetALD的参与者中探索酒精摄入量和全因死亡率之间的关系:基于NHANES III数据的研究]
1Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China.
概括
较高的酒精摄入量增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与酒精有关的肝病 (MetALD) 患者的死亡风险. 适度和高消费水平与明显更高的全因死亡率有关.
科学领域:
- 肝病学和胃肠道学
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生和流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与酒精有关的/相关的肝病 (MetALD) 是严重的公共卫生问题.
- 了解酒精消费对这些患者群体死亡率的影响,对于临床管理和预防策略至关重要.
研究的目的:
- 调查日常饮酒量不同程度与全因死亡率之间的关联.
- 评估这些风险,特别是在被诊断为MASLD和MetALD的患者队伍中.
主要方法:
- 来自第三次国家健康和营养检查调查 (NHANES III) (1988-1994) 数据的分析.
- 包括2322名年龄在20-74岁之间的参与者,肝脏肥胖症通过超声波确认.
- 考克斯比例风险回归建模用于计算低,中等和高酒精摄入群体所有原因死亡率的调整危险比率 (aHR).
主要成果:
- 适度 (aHR=1.37,P=0.002) 和高 (aHR=1.45,P=0.001) 的每日酒精摄入量独立地与增加全因死亡率有关.
- 每人年死亡率为1.38% (低),1.67% (中等) 和2.10% (高).
- 亚组分析显示,在60岁以下的非2型糖尿病 (T2DM) 参与者中,酒精水平之间的死亡风险存在显著差异.
结论:
- 酒精消费对患有MASLD和MetALD的个体具有剂量依赖的负面影响.
- 增加酒精摄入量与这些肝病患者全因死亡风险更高显著相关.
- 这些发现强调了戒酒或减少饮酒对于被诊断患有脂肪肝疾病的患者的重要性.
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