康迪塞宾与抗氧化剂作用相结合,可以改善过度运动引起的疲劳
Chunfang Cheng1, Shasha Zhang1, Chong Chen1,2,3
1School of Sport Science, Jiangxi Science and Technology Normal University, Nanchang, 330013, Jiangxi, People's Republic of China.
Scientific reports
|March 10, 2025
概括
源自Cordyceps militaris的Cordicepin通过增加耐力和减少氧化应激来对抗运动引起的疲劳. 它还可以改善过度炼小鼠的认知功能和学习.
科学领域:
- 运动生理学 运动生理学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度运动会破坏抗氧化剂系统,导致疲劳,神经损伤和认知能力下降.
- 科迪塞宾是Cordyceps militaris中的一个关键化合物,具有抗炎,抗氧化和神经保护性质.
- 了解康迪塞的抗疲劳机制对于开发针对运动诱导损伤的干预措施至关重要.
研究的目的:
- 在过度运动的小鼠模型中研究cordycepin的抗疲劳作用.
- 阐明潜在的机制,包括对氧化应激,代谢物,神经递质和特定信号通路的影响.
- 评估cordycepin对学习和记忆等认知功能的影响.
主要方法:
- 强迫运动小鼠模型被用来诱导疲劳和相关的生理变化.
- 考迪塞口服对其对运动耐力,能量储备 (糖原) 和疲劳标志物的影响进行了评估.
- 在体外和体内测试测量了氧化应激标志物,神经递质水平和Keap1/Nrf2/HO-1通路. 行为测试评估学习和记忆.
主要成果:
- 科迪塞宾显著提高了运动耐力,并增加了肝脏和肌肉中的糖原含量.
- 它降低了疲劳代谢物 (乳酸,BUN) 和氧化应激标志物 (MDA) 的水平,同时增加了抗氧化酶活性 (SOD).
- 科迪塞平改善了过度炼小鼠的学习和记忆缺陷,调节了神经递质水平,并激活了Keap1/Nrf2/HO-1通路,增加了BDNF.
结论:
- 科尔迪塞显示出显著的抗疲劳作用,改善身体表现和减轻运动引起的生理损伤.
- 该化合物通过减少氧化应激和调节神经递质平衡来缓解与过度运动相关的认知障碍.
- 科迪塞的机制包括激活Keap1/Nrf2/HO-1通路并增强BDNF,支持其作为抗疲劳剂的潜力.
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