评估不同的指数,以测量脉动性模拟循环循环中大动脉的弹性特性
Jeremy Jarman1, Daniel Navarro1, Johanna Ticar1
1Ascense Medical GmbH, Vienna, Austria.
概括
大动脉硬度随着血压显著变化,影响了如何测量弹性. 目前的公式不能在不同压力下提供一致的大动脉硬度值,强调需要改进的测量方法.
科学领域:
- 心血管生理学心血管生理学
- 生物机械工程 生物机械工程
- 医疗器械测试 医疗器械测试 医疗器械测试
背景情况:
- 大动脉硬是心血管健康的关键指标.
- 测量大动脉刚性的现有方法可能会受到负载条件的影响.
- 了解这些影响对于准确的临床评估至关重要.
研究的目的:
- 评估用于量化大动脉硬度的不同指数.
- 为了确定不同血压条件对这些测量的影响.
- 在不同的负载场景下评估各种大动脉硬度公式的一致性.
主要方法:
- 猪和绵羊胸前动脉在脉动性模拟循环中进行ex vivo测试.
- 在保持恒定的心率,中风体积和脉冲压力的同时,增加腹压的应用.
- 分析数据使用多种既定公式来分析应变,合规性,延展性,脉冲波速度和弹性模块.
主要成果:
- 绵羊的大动脉与猪大动脉相比,具有更高的弹性,压力下的直径变化更大.
- 所有测试的大动脉样本都显示了随着血压升高而增加的硬度 (P < 0.001).
- 大多数测量公式显示了显著的压力依赖变化,除了在正常压力范围内的猪样本中的非对数刚度指数.
结论:
- 大动脉弹性受到血压水平的显著影响.
- 目前对大动脉硬度的指数在一系列生理压力中缺乏一致性.
- 开发一种新的,一致的大动脉硬度测量公式是有必要的,以提高临床效用.
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