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经期的年龄和冠状动脉疾病风险:与不同来源变化的不同关联

Ambreen Sonawalla^1,2, Daniel I Chasman^2,3, Yee-Ming Chan^1,2

¹Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital.

The Journal of clinical endocrinology and metabolism

|March 10, 2025

概括

初潮的早期年龄 (AAM) 增加了冠状动脉疾病 (CAD) 的风险. 晚期AAM风险与非遗传因素有关,而不是AAM本身,可能由代谢变化介导.

科学领域:

遗传学是一个遗传学.
心血管疾病流行病学
生殖健康生殖健康

背景情况:

初潮时的早期和晚年 (AAM) 都与女性冠状动脉疾病 (CAD) 风险增加有关.
研究影响AAM的遗传和非遗传因素的不同作用对于了解CAD风险至关重要.
这项研究区分了常见遗传变异 (多基因分数 - PGS) 与其他因素对AAM-CAD关系的影响.

研究的目的:

为了确定AAM和CAD风险因素之间的关联是否根据AAM变化的来源有所不同.
为了区分基因预测的AAM和受环境或罕见遗传因素影响的AAM的影响.

主要方法:

利用英国生物库 (201,037名女性) 和女性基因组健康研究 (23,268名女性) 的数据.
计算的AAM多基因分数 (PGS) 和衍生的基因预测的AAM和PGS调整的AAM.
使用后勤回归和线性线条来分析与CAD和CAD风险因素的关系.

主要成果:

基因预测的AAM显示与CAD及其风险因素的线性关联.
经PGS调整后的AAM与CAD,HbA1c,甘油三,HDL-C和腰比呈现出U形关系.
这表明影响AAM的非遗传因素是后来的AAM-CAD关联的关键.

结论:

早期的AAM因果上增加了CAD风险.
晚期的AAM似乎不会直接导致CAD风险增加;非遗传因素是相关的.
糖尿病血糖,脂质不良和中心脂肪是晚期AAM与CAD风险增加之间的关联的潜在媒介.

关键词:

英国生物银行多基因分数的多基因分数.青春期的时间表女人女人女人女人女人

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