精神病多基因风险评分和双极性障碍青年每周症状状况:一项探索性研究
Xinyue Jiang1,2, Clement C Zai1,3,4,5, John Merranko6
1Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada.
Journal of child and adolescent psychopharmacology
|March 10, 2025
概括
对双相情感障碍 (BD) 和相关疾病的多基因风险评分 (PRSs) 在患有BD的年轻人中进行了检查. 对精神分裂症和严重抑郁症的更高得分与随访期间更多的情绪症状和更短的情绪缓解时间有关.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 儿童和青少年心理健康
背景情况:
- 双极性障碍 (BD) 是成人和青少年的一种多遗传性疾病.
- 之前的研究还没有探索多基因风险评分 (PRSs) 与青少年患有BD的纵向情绪症状过程相关.
研究的目的:
- 这项研究旨在调查PRS与BD,精神分裂症 (SCZ),严重抑郁症 (MDD) 和注意力缺陷/多动症 (ADHD) 之间的关联,以及BD年轻人的情绪症状的前性进程.
主要方法:
- 包括246名年轻人 (7-20岁) 具有欧洲血统的BD.
- 评估了168名参与者的摄入和前性情绪症状严重程度,平均为8.7年.
- 构建了BD,SCZ,MDD和ADHD的PRS,使用来自独立成年群体的全基因组总结统计数据.
主要成果:
- 较高的BD-PRS与服用时更低的终身抑郁症严重程度有关.
- 在随访期间,较高的SCZ-PRS和MDD-PRS与更短的时间在euthymia和更长的时间与副综合征情绪症状相关.
- 对于BD和ADHD的PRS显示,与纵向情绪变量没有显著的关联.
结论:
- 这项探索性分析是首次将精神病学PRS与患有BD的年轻人未来情绪症状过程有关的.
- 研究结果表明,SCZ/MDD风险和青少年BD的情绪症状轨迹之间存在潜在的遗传联系.
- 结果可以为未来关于这个主题的大规模研究提供信息.
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