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在急性胰腺炎感染期间,托芬通路的代谢变化
Daosheng Wang1,2, Silei Sun1, Qianli Zhao2
1Department of Emergency.
JCI insight
|March 10, 2025
概括
肠道三甲代谢的干扰,特别是血清素的减少,与急性胰腺炎 (AP) 的感染性并发症有关. 托代谢物可以作为AP管理的生物标志物和治疗点.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 急性胰腺炎的传染性并发症 (ICs) 增加了死亡率和住院时间,通常是由细菌转移驱动的.
- 肠道微环境在AP病变发生中的代谢作用,特别是关于ICs的代谢作用,尚不清楚.
研究的目的:
- 调查肠道代谢组与AP患者和小鼠模型中ICs发展之间的关系.
- 确定潜在的生物标志物和治疗目标,用于AP中管理IC.
主要方法:
- 人类患者队列和小鼠研究.
- 肠道和血样本的代谢分析.
- 涉及免疫反应 (Th17) 和代谢物管理的机制研究.
主要成果:
- 肠道中血清激素和内醇通路的减少,以及 kynurenine 通路代谢物的增加,与 AP 中的 IC 发生有关.
- 由托代谢物调节的受损的肠道Th17反应在IC发育中至关重要.
- 氨酸补充剂降低了IC发病率,而氨酸则加剧了感染.
结论:
- 托方代谢物显著影响AP病原和IC发育.
- 特定的托代谢物显示出作为ICs预测生物标志物的潜力.
- 准托代谢为AP相关的IC提供了一个有前途的治疗策略.
相关概念视频
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Acute Pancreatitis II: Clinical Manifestations and Management
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
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Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
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