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围产期双暴露和怀孕年龄较小的新生儿:当时和现在替代物的演变效应

Lin Luo^1,2, Chang Gao^1,2, Yi-Jun Fan³

¹School of Public Health and Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei 230032, China.

Environmental science & technology

|March 10, 2025

概括

怀孕期间接触传统双A (BPA) 替代品与妊娠年龄小 (SGA) 后代的风险更高有关. 新兴的BPA替代品与SGA的相关性较低,可能由胎盘功能介导.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
发育儿科发育儿科

背景情况:

双相似物表现出雌激素活性,并可能影响胎儿发育.
有限的人类数据存在于新兴双替代品的围产期暴露和怀孕年龄 (SGA) 的小.
调查胎盘功能在调解双暴露和SGA中的作用至关重要.

研究的目的:

检查对双相似物周产期暴露与人类SGA风险之间的关联.
评估胎盘功能的调解作用在双暴露和SGA之间的关系.
为了比较传统双A (BPA) 替代品与新兴替代品相关的风险.

主要方法:

在1054名孕妇的尿液中量化了双相似物.
使用后勤回归和混合效应模型 (贝叶斯核机器回归,基于量子的g计算) 来评估SGA风险.
调解分析被用来调查胎盘功能 (乙) 在暴露-SGA关系中的作用.

主要成果:

双A (BPA) 和其传统替代品 (BPB,BPE,BPAP) 与增加SGA风险相关 (ORs>1.80,P <0.05).
新兴的双替代品显示,尽管检测频率高,但风险减弱.
同时暴露于双醇与SGA风险显著相关 (OR = 2.70,P < 0.001),由BPA和传统替代品驱动.
胎盘雌醇水平调解了BPA-BPE-BPAP-SGA关系,BPBP显著贡献 (25.4%).

结论:

与新兴替代品相比,传统的双A替代品对后代发育 (SGA) 的风险更高.
胎盘功能受损,特别是雌醇水平,调解了某些双暴露和SGA之间的关联.
对于新出现的双毒性评估,需要进一步的研究和验证研究.

关键词:

这是一种双醇类似物.新兴的替代品新兴的替代品雌醇 (Estriol) 是一种醇.混合物效应的混合物效应.围产期的暴露时间胎盘功能指数胎盘功能指数对于怀孕年龄来说小的新生儿

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