父亲遗传对创伤后应激障碍和内化和外化障碍风险的作用是什么?
Ananda B Amstadter1,2, Linda Abrahamsson3, James E Hart1,2
1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Psychological medicine
|March 10, 2025
概括
父亲的创伤后应激障碍 (PTSD) 会增加后代患PTSD和严重抑郁症 (MD) 的风险,这表明遗传. 跨疾病遗传风险与内部化与外部化疾病模式保持一致.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 研究精神疾病的跨代传播对于理解病因至关重要.
- 需要新的遗传-流行病学方法来解开遗传和环境的影响.
- 创伤后应激障碍 (PTSD),严重抑郁症 (MD),酒精使用障碍 (AUD) 和药物使用障碍 (DUD) 是具有共同风险因素的遗传性疾病.
研究的目的:
- 为了检查PTSD,MD,AUD和DUD的跨代遗传传染.
- 为了利用这部小说的母亲半兄弟姐妹家庭与不和的父亲 (MHSFDF) 设计进行这项调查.
- 根据父亲的诊断,评估后代的内部和跨境风险.
主要方法:
- 使用瑞典国家注册的MHSFDF设计.
- 鉴定了72,467对母性半兄弟姐妹,他们一起长大,父亲的诊断不一致.
- 包括与受影响父亲接触有限 (<1年) 的后代,以尽量减少环境混.
主要成果:
- 父亲的PTSD显著增加了后代患PTSD (HR: 1.43) 和MD (HR: 1.55) 的风险.
- 父亲的PTSD并没有提高外化障碍 (AUD,DUD) 的风险.
- 父亲患有AUD,DUD或MD的后代显示PTSD风险增加,表明这些疾病的基因风险共享.
结论:
- 这项研究提供了使用MHSFDF设计的PTSD跨代遗传的第一个证据.
- 研究结果支持在遗传风险传播方面将内化和外化疾病区分开来.
- 结果强调了遗传因素在几代人之间发展精神疾病的复杂相互作用.
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