由非HACEK阴性细菌引起的感染性内心炎,一个基于注册表的比较研究
Jasmina Al Janabi1, Mohammed El Noaimi1, Torgny Sunnerhagen1,2
1Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Open forum infectious diseases
|March 10, 2025
概括
感染性内心炎 (IE) 由非HACEK细菌 (nHGNB) 引起的不常见. 虽然Pseudomonas aeruginosa和Serratia marcescens现在被认为是典型的病原体,但它们的纳入并没有改善诊断标准的性能.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 心脏病学 心脏病学
背景情况:
- 感染性内心炎 (IE) 是由非HACEK细菌 (nHGNB) 引起的,很少见.
- 2023年杜克-ISCVID标准现在将Pseudomonas aeruginosa和Serratia marcescens列为典型的IE病原体.
- 本研究研究了这种分类的含义和nHGNB IE的特征.
研究的目的:
- 评估患有nHGNB细菌病的患者的IE风险.
- 分析由nHGNB物种引起的IE的特征.
- 评估将P. aeruginosa和S. marcescens归类为典型的IE病原体对诊断标准的影响.
主要方法:
- 从瑞典传染性内心炎 (SRIE) 登记处 (2008-2023) 追溯分析nHGNB IE病例.
- 将IE病例与nHGNB细菌病的对照病例进行比较.
- 对nHGNB IE的杜克-ISCVID标准表现的评估.
主要成果:
- 发现了114次nHGNB IE (1.5%的所有IE病例).
- 大肠杆菌是最常见的原因 (28%),其次是P. aeruginosa (13%) 和Klebsiella (9%).
- P. aeruginosa和Serratia在IE中比细菌病更为普遍,但Duke-ISCVID标准的表现没有改善.
结论:
- 在IE中,P. aeruginosa和Serratia比细菌病更为常见.
- 将P. aeruginosa和Serratia归类为典型的IE病原体并没有提高Duke-ISCVID标准的有效性.
- 与链球菌IE相比,nHGNBIE与常见的潜在疾病和更高的死亡率有关.
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