持续时间不匹配自闭症谱系障碍成年人的消极性与健康对照对比
Aya Sato1, Shuntaro Itagaki1, Takashi Ohnishi2
1Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Neuropsychiatric disease and treatment
|March 10, 2025
概括
与健康对照组相比,患有自闭症谱系障碍 (ASD) 的成年人表现出较短的持续时间不匹配负面性 (d-MMN) 延迟时间. 这表明,在ASD中听觉过敏可能会持续到成年.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 临床心理学 临床心理学
背景情况:
- 不匹配负面性 (MMN) 衡量自动审计处理.
- 在患有自闭症谱系障碍 (ASD) 的儿童中观察到MMN振幅的减少.
- 持续时间MMN (d-MMN) 是精神分裂症的一个稳定生物标志物.
研究的目的:
- 与健康对照组 (HCs) 相比,在患有自闭症的成年人中研究d-MMN.
- 确定潜在的生物标志物,以区分患有自闭症的成年人.
主要方法:
- 用于测量d-MMN的听觉奇怪任务.
- 参与者:15名患有自闭症的成年人和20名HC (20-40岁).
- 排除标准:智商低,使用中枢神经系统刺激剂,过度饮酒.
主要成果:
- 与HC相比,患有自闭症的成年人在Fz和Cz时表现出明显较短的d-MMN延迟时间.
- 这一发现表明ASD成年人的自动听觉处理发生了变化.
结论:
- 在ASD中缩短d-MMN延迟可能反映到成年时持续的听觉过敏.
- d-MMN 延迟可以作为患有自闭症的成年人的潜在诊断工具.
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