牙周炎和阿尔茨海默氏病之间的关联:一个叙事审查
Mohammad Amin Seyedmoalemi1, Zahra Saied-Moallemi2
1Research Assistant, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
IBRO neuroscience reports
|March 10, 2025
概括
牙周炎是一种牙疾病,通过促进大脑炎症,可能会导致阿尔茨海默病 (AD). 针对P. gingivalis等口腔病原体可能为AD预防和管理提供新的策略.
科学领域:
- 口腔健康 口腔健康
- 神经退行性疾病 神经退行性疾病
- 炎症过程 炎症过程
背景情况:
- 牙周炎是一种慢性炎症性牙疾病,与牙脱落有关.
- 阿尔茨海默病 (AD) 是一种神经退行性疾病,其特点是认知能力下降和大脑炎症.
- 新出现的证据表明牙周炎和AD病原体之间存在联系.
研究的目的:
- 探索牙周炎在阿尔茨海默病的发展和进展中的潜在作用.
- 为了研究口腔病原体和AD中神经炎症之间的联系.
主要方法:
- 对检查共享风险因素和生物机制的临床和实验研究的审查.
- 在AD患者的大脑组织中检测牙周病原体.
主要成果:
- 牙周病原体,如 Porphyromonas gingivalis,已在阿尔茨海默氏症患者的大脑中发现.
- 这些病原体可能会通过激活微质细胞和促进全身炎症来加剧神经炎症,这是AD的关键因素.
结论:
- 牙周炎可能是导致阿尔茨海默病的一个因素.
- 向牙周炎和P. gingivalis等特定病原体可能为AD预防和管理提供新的治疗策略.
相关概念视频
01:15Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
01:21Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
01:30Other Disorders of Digestive System
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
01:30Tonsillitis I: Introduction
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
01:26Assessment of the Mouth
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...