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吉林吉囊通过促进体内洞穴体中依赖于的血管生成来增强勃起功能

Xujun Yu¹, Jingyi Zhang², Suyun Xu³

¹School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Journal of traditional and complementary medicine

|March 10, 2025

概括

吉林吉囊 (GLJC) 通过增强的利用和促进血管生成来治疗勃起功能障碍 (ED). 治疗涉及调节FGF2,RICTOR/P-AKT/P-FOXO1通路,以一种依赖于的方式.

科学领域:

传统中国医药传统中国医药
药理学药理学是指药理学的学科.
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

勃起功能障碍 (ED) 是一种普遍影响男性性健康的疾病.
吉林吉囊 (GLJC) 是一种传统中医药配方,用于治疗勃起障碍.
在ED治疗中GLJC的有效性背后的精确机制尚未完全阐明.

研究的目的:

探索GLJC在治疗ED中的潜在分子机制.
确定GLJC对ED治疗效果的关键目标和途径.
通过体内实验验证这些机制.

主要方法:

对GLJC组件和ED相关目标的网络药理学分析.
分子对接以评估GLJC组件与已识别的目标的结合亲和力.
在体内验证使用d-银糖诱导衰老的老鼠模型和切切除的老鼠.

主要成果:

网络药理学确定了雄激素受体 (AR) 和纤维细胞生长因子2 (FGF2) 作为关键标.
分子对接证实了GLJC组件与AR和FGF2的有效结合.
在老老鼠中,GLJC治疗增加了勃起频率,血清自由和阴茎AR表达.
通过调节FGF2,RICTOR/P-AKT/P-FOXO1信号传递,GLJC促进了血管生成并抑制了阴茎纤维化.

结论:

GLJC通过增强激素利用率和以激素依赖的方式促进血管生成来治疗ED.
这种机制涉及调节FGF2,RICTOR/P-AKT/P-FOXO1信号通路.
GLJC促进体洞的生存,并抑制阴茎纤维化,为ED提供潜在的治疗策略.

关键词:

血管新生的产生.中国传统的中国传统传统.勃起功能障碍是因为勃起功能障碍.医学医学医学医学医学网络药理学网络药理学测试激素测试激素是什么

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