Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.3K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.3K
Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

106
Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
106

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Impact and outcomes after desensitization therapy in highly sensitized heart transplant candidates.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025
Same author

Exon Utilization Improves Risk Stratification for Advanced Heart Failure in Titin Cardiomyopathy.

medRxiv : the preprint server for health sciences·2025
Same author

Mucin 1 antigen mimetic functionalized mannosylated peptide nanofibers for antigen uptake and immune modulation.

Biomaterials science·2025
Same author

Clinical Characteristics and Outcomes Associated With Immediate Versus Delayed Presentation of Severe Primary Graft Dysfunction After Heart Transplantation: Does Timing Matter?

Clinical transplantation·2025
Same author

Therapeutic Peptides, Proteins and their Nanostructures for Drug Delivery and Precision Medicine.

Chembiochem : a European journal of chemical biology·2024
Same author

Therapeutic synthetic and natural materials for immunoengineering.

Chemical Society reviews·2024
Same journal

Understanding glycan structure and function through artificial intelligence.

BBA advances·2026
Same journal

Role of recombinant S100A13 expression in regulating mitochondrial fission and fusion in lung epithelial cells.

BBA advances·2026
Same journal

Lysosomal membrane permeabilization is involved in CYP2E1-induced apoptosis in hepatocellular carcinoma cells.

BBA advances·2026
Same journal

miR-765 induces angiogenesis by inhibiting dipeptidyl peptidase 4 and increasing fibroblast growth factor 2.

BBA advances·2026
Same journal

Drying parameters and aging modulate protective properties of vitrified trehalose.

BBA advances·2026
Same journal

AGTRAP mediates exosome-driven communication between cancer cells and macrophages via p38 MAPK pathway to promote hepatocellular carcinoma.

BBA advances·2026
查看所有相关文章

相关实验视频

Updated: May 23, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

212

用于诊断和治疗的蛋白质识别方法.

Ryne Montoya1, Peter Deckerman1, Mustafa O Guler1

  • 1The Pritzker School of Molecular Engineering, The University of Chicago, 5640 S Ellis Ave Chicago, IL 60637 USA.

BBA advances
|March 10, 2025
PubMed
概括
此摘要是机器生成的。

对生物系统至关重要的蛋白质识别,依赖于分子相互作用. 鉴定和人工智能的进步增强了对诊断和治疗的理解和预测,尽管复杂的细胞环境仍然存在挑战.

关键词:
抗体是一种抗体.诊断 诊断 诊断 诊断酵素酶是一种酶.免疫治疗是一种免疫疗法.蛋白质 蛋白质 蛋白质

更多相关视频

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

4.9K
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

13.9K

相关实验视频

Last Updated: May 23, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

212
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

4.9K
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

13.9K

科学领域:

  • 分子生物学分子生物学
  • 生物化学 生化学
  • 计算生物学 计算生物学

背景情况:

  • 蛋白质识别机制是生物系统的基础.
  • 这些相互作用对诊断和治疗至关重要.
  • 具体性依赖于结构,动态和生化因素,包括分子力.

研究的目的:

  • 探索蛋白质识别的机制.
  • 突出先进工具在理解这些相互作用中的作用.
  • 讨论诊断和治疗方面的应用,并确定未来的挑战.

主要方法:

  • 使用先进的表征工具来研究蛋白质相互作用.
  • 使用人工智能,分子对接和模拟等计算方法.
  • 研究调控结合特异性的分子力量.

主要成果:

  • 提高对蛋白质相互作用动力学和热力学的理解.
  • 提高了分子相互作用和结合部位的预测准确性.
  • 确定蛋白质识别在诊断 (例如ELISA,生物传感器) 和治疗 (例如药物设计) 中的关键作用.

结论:

  • 蛋白质识别对于诊断和药物开发至关重要.
  • 尽管取得了进展,但在理解复杂的细胞环境中的相互作用方面仍然存在挑战.
  • 未来的研究应该专注于加强临床转化检测和查.