与血清Klotho水平相关的体质指数类别中的代谢健康:基于人口的研究
Yanling Shu1,2, Junfan Yang3,4, Linfei Dou3
1Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in endocrinology
|March 10, 2025
概括
代谢不健康的个体,尤其是女性,血清中Klotho水平较低,这是衰老的生物标志物. 这表明新陈代谢健康和体重指数 (BMI) 影响衰老过程.
科学领域:
- 老年学和新陈代谢健康
- 衰老的生物标志物
- 肥胖和新陈代谢 肥胖和新陈代谢
背景情况:
- 代谢健康和体重指数 (BMI) 对于预测与年龄相关的疾病和死亡率至关重要.
- 血清克洛托,一个衰老的生物标志物,与代谢状态和BMI有关,但这种关系尚未完全理解.
- 调查BMI类别的新陈代谢健康表型及其与血清Klotho水平的关联对于了解衰老至关重要.
研究的目的:
- 检查按BMI分类的新陈代谢健康表型与中年和老年人血清Klotho水平之间的关联.
- 确定代谢健康状况如何与不同BMI类别相互作用,以影响衰老生物标志物.
- 为了解代谢功能障碍,肥胖和衰老相关的生物机制提供见解.
主要方法:
- 分析了11413名参与者的大量队列.
- 根据代谢健康和BMI,参与者被分为六种表型:代谢健康的正常体重 (MH-NW),代谢健康的超重 (MH-OW),代谢健康的肥胖 (MHO),代谢不健康的正常体重 (MU-NW),代谢不健康的超重 (MU-OW) 和代谢不健康的肥胖 (MUO).
- 使用权重多变量线性回归模型来评估这些表型与血清Klotho水平之间的关系.
主要成果:
- 代谢上健康的超重 (MH-OW),代谢上不健康的超重 (MU-OW) 和代谢上不健康的肥胖 (MUO) 组与代谢上健康的正常体重 (MH-NW) 组相比,血清Klotho水平显著降低.
- 克洛托水平的估计百分比变化为MH-OW的-5.4%,MU-OW的-5.0%,MUO的-5.7%,相对于MH-NW.
- 降低Klotho水平在MU-OW (-6.6%) 和MUO (-8.4%) 表型的女性中更为明显,这表明性别特异性影响.
结论:
- 血清Klotho水平受到代谢健康状况和BMI类别的相互作用的显著影响.
- 无论BMI如何,新陈代谢不健康的表型与较低的Klotho水平有关,这表明加快衰老.
- 这些发现强调了代谢异常和身体脂肪对衰老过程的影响,并突出了潜在的干预目标.
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