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相关概念视频

Olfaction01:25

Olfaction

44.1K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

7.8K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
7.8K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

8.7K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
8.7K

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Updated: May 23, 2025

Author Spotlight: Exploring Glial Influence in Experience-Dependent Synaptic Pruning During Critical Periods
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排斥性相互作用指示突触伴侣在嗅觉回路中匹配.

Zhuoran Li1,2,3, Cheng Lyu1,3, Chuanyun Xu1,2

  • 1Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

bioRxiv : the preprint server for biology
|March 10, 2025
PubMed
概括

排斥性细胞表面蛋白质对引导发育大脑中的神经元连接. 这些相互作用防止了错误的突触伴侣匹配,确保了电路的准确性.

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Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 神经元通过细胞表面蛋白 (CSP) 形成精确的连接.
  • 吸引力CSP指导突触伙伴匹配,但排斥性CSP的作用不太了解.

研究的目的:

  • 调查排斥性CSP在Drosophila发育中的嗅觉回路中的突触伴侣匹配中的作用.

主要方法:

  • 使用单细胞转录组进行基因选.
  • 识别和分析中介排斥性相互作用的CSP对.

主要成果:

  • 确定了三个CSP对 (Toll2-Ptp10D,Fili-Kek1,Hbs/Sns-Kirre) 在非伴侣神经元之间调解排斥.
  • CSP对显示了反向表达模式和功能相互依赖.
  • 在CSP中的功能丧失导致了突触合作伙伴匹配赤字.

结论:

  • 多个排斥性CSP对积极防止错误的神经元连接.
  • 这些排斥性相互作用对于在发育过程中精确的突触伴侣匹配至关重要.