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Updated: May 23, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Published on: February 21, 2018

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RBM15-MKL1融合蛋白通过m6A甲基化和WNT通路激活促进白血病

Madeline Y Mayday, Giulia Biancon, Manyi Wei

    bioRxiv : the preprint server for biology
    |March 10, 2025
    PubMed
    概括

    由RBM15-MKL1 (RM) 驱动的急性巨核细胞白血病 (AMKL) 依赖于N6-甲基氨酸 (m6A) 修饰. 抑制METTL3,一个m6A编写器,通过影响Wnt信号和Frizzled基因表达来准RM-AMKL.

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