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周产期尼古丁暴露破坏了造血干细胞的发育,并提高了成年人患流感的易感性

T Cool^1,2, A Rodriguez Y Baena^1,2, Mge Rommel²

¹Program in Biomedical Science and Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

bioRxiv : the preprint server for biology

|March 10, 2025

概括

周产期尼古丁暴露会损害免疫细胞的发育,导致成年人终身易受流感等呼吸道感染. 这是由于免疫细胞功能的持久变化而发生的,而不仅仅是数字.

科学领域:

免疫学免疫学免疫学
发展生物学发展生物学
呼吸系统医学呼吸系统医学

背景情况:

怀孕期间吸烟对母亲和胎儿的健康构成风险.
吸烟母亲的后代表现出呼吸系统疾病的频率和严重程度的增加.
改变的免疫系统,可能来自表观遗传不适应性造血干细胞 (HSC),可能是这种脆弱性的基础.

研究的目的:

研究围产期尼古丁暴露对免疫细胞发育和功能的长期影响.
阐明产前吸烟暴露增加了对呼吸道感染的易感性的机制.

主要方法:

在一个模型系统中,围产期尼古丁暴露 (PNE).
对造血干细胞 (HSC) 和免疫细胞群的分析.
在成年时对流感A病毒的免疫反应和疾病严重程度的评估.

主要成果:

PNE改变了HSC建立和胎儿衍生的非传统组织免疫细胞,循环免疫细胞没有变化.
在PNE停止后,免疫细胞抑制持续了数周.
在成年期,PNE导致流感A感染的易感性和严重性增加,这与肺部免疫细胞的改变有关.

结论:

围产期暴露可以通过影响造血系统,永久性地损害免疫功能.
在发育过程中暴露于尼古丁会产生持久的细胞缺陷,在一生中削弱对呼吸道病原体的防御能力.

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