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Updated: May 23, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

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人类TWIK-2通道的结构及其通过皮莫齐德的抑制

Nandish K Khanra, Chongyuan Wang, Bryce D Delgado

    bioRxiv : the preprint server for biology
    |March 10, 2025
    PubMed
    概括

    研究人员确定了TWIK-2通道的冷EM结构,揭示了独特的特征和抑制剂的结合部位. 发现药物皮莫齐德可以抑制TWIK-2,为新的抗炎疗法提供了基础.

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    Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay10:41

    Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

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