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Updated: May 23, 2025

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting
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在发育过程中激活KCC2可以减轻成年CDKL5缺乏的小鼠的认知,行为和神经刺激能力

Muhammad Nauman Arshad, Christopher Bope, Jacob S Dengler

    bioRxiv : the preprint server for biology
    |March 10, 2025
    PubMed
    概括

    在婴儿CDKL5缺乏障碍 (CDD) 鼠标模型中,使用KCC2激活剂 (OV350) 的早期干预可以预防和认知缺陷. 这突出了KCC2作为CDD的治疗点,强调了在关键发育窗口期间早期治疗的重要性.

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