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Updated: Jun 23, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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一个全基因组的CRISPR屏幕揭示了长寿血细胞分泌能力的新型决定因素

Lucas J D'Souza1, Jonathan N Young2,3, Heather Coffman2,4

  • 1Department of Immunobiology, University of Arizona; Tucson, AZ.

bioRxiv : the preprint server for biology
|March 10, 2025
PubMed
概括

研究人员确定了调节血细胞寿命和抗体分泌的关键因素. V型ATPases和PI4KB增强囊泡酸化和抗体产生,而DDX3X影响免疫球蛋白分泌. MYD88还在血细胞存活中发挥作用.

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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Performing an In Vitro Genome-Wide CRISPR Knockout Screen in Chimeric Antigen Receptor T Cells07:37

Performing an In Vitro Genome-Wide CRISPR Knockout Screen in Chimeric Antigen Receptor T Cells

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相关概念视频

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...