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Updated: Jun 19, 2026

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
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Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

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乳牛H5N1流感病毒糖蛋白进化复制复合囊泡性口腔炎病毒模型

Lindsey R Robinson-McCarthy1,2, Kylie E Zirckel1, Holly C Simmons1

  • 1Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

bioRxiv : the preprint server for biology
|March 10, 2025
PubMed
概括

携带禽流感H5N1基因的新型重组囊泡性口腔炎病毒 (rVSV-H5N1dc2024) 有助于对病毒耐药性和抗体逃逸的研究,加速了对这种动物性疾病威胁的干预开发.

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相关概念视频

Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...