相关实验视频

Updated: May 23, 2025

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

16.2K

氨酸15促进皮肤表皮的基底氨酸细胞中的原始细胞状态

Catherine J Redmond, Sarah N Steiner, Erez Cohen

    bioRxiv : the preprint server for biology
    |March 10, 2025
    PubMed
    概括

    氨酸15 (K15) 通常将YAP1隔离起来,以防止氨酸细胞的分化. 特定的K15结构变化损害了这种功能,影响了皮肤原生细胞状态.

    更多相关视频

    Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin10:51

    Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

    Published on: July 14, 2017

    30.7K
    Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis09:16

    Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

    Published on: December 14, 2015

    11.2K

    相关概念视频

    Renewal of Skin Epidermal Stem Cells01:12

    Renewal of Skin Epidermal Stem Cells

    The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
    2.4K
    Cells of the Epidermis01:24

    Cells of the Epidermis

    The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
    The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
    3.6K
    Layers of the Epidermis01:21

    Layers of the Epidermis

    The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
    Stratum Basale
    Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
    3.6K
    Multipotency and Niche of Bulge Stem Cell01:06

    Multipotency and Niche of Bulge Stem Cell

    A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
    3.3K
    Pigmentation01:19

    Pigmentation

    The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
    Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
    2.3K
    Papillary Dermis01:11

    Papillary Dermis

    Dermis
    The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
    Papillary Layer
    The papillary layer is made of loose, areolar connective tissue, which means the collagen...
    2.5K