用纳米载体对瘤进行向治疗的进展:一篇综述
Hongxia Cheng1,2,3, Juan Liao1,2,4, Yuhan Ma1,2,3
1Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan, 430074, China.
Materials today. Bio
|March 10, 2025
概括
纳米载体 (NCs) 通过改善药物输送和克服耐药性来增强化疗. 本综述详细介绍了NC类型,管理和向改善癌症治疗,建议大小,形状和表面修改.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统化疗面临着诸如药物输送不良,低生物可用性和多药耐药性等挑战.
- 纳米载体 (NCs) 通过保护药物并使其在目标部位准确释放,提供了一个解决方案.
- 现有的NCs审查往往缺乏针对性治疗的不同NC类型的详细分析.
研究的目的:
- 系统地审查针对癌症治疗的各种纳米载体的优缺点.
- 分析瘤微环境 (TME),施用途径和向途径对治疗疗效的影响.
- 确定提高纳米载体准能力的策略.
主要方法:
- 有机,无机和混合纳米载体的综合文献综述.
- 影响向治疗的因素分析:TME,给药方式 (静脉注射,口服,腔内注射) 和向途径 (被动,活性).
- 检查特定的纳米载体系统:聚合物NCs,树脂体,体,脂质体,半孔NCs,黄金NCs,量子点,纳米粘土,核心NCs和MOFs.
主要成果:
- 详细比较针对性治疗的不同纳米载体类型的优缺点.
- 确定TME,注射途径和向机制作为治疗成功的关键因素.
- 评估各种纳米载体平台,包括聚合物,基于脂质,无机和混合系统.
结论:
- 纳米载体通过解决传统药物的局限性,显著提高化疗疗效.
- 优化纳米载体特性 (大小,形状,表面特性) 对于提高向治疗效率至关重要.
- 对纳米载体设计和应用的进一步研究对于推进癌症治疗至关重要.
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