心力衰竭与保存的射出分数和与代谢功能障碍相关的脂肪性肝病:双重挑战,一种代谢溶液
Li-You Lian1, Chen-Xiao Huang1, Qin-Fen Chen2
1MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
World journal of cardiology
|March 10, 2025
概括
保存喷射分数 (HFpEF) 的心力衰竭和与代谢功能障碍相关的脂肪性肝病 (MASLD) 具有共同的代谢联系,这给治疗带来了挑战. 综合代谢和心血管保健,包括SGLT2抑制剂,是改善患者治疗结果的关键.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 现在,心力衰竭与保留喷射分数 (HFpEF) 比心力衰竭与减少喷射分数 (HFrEF) 更为普遍.
- 与HFrEF不同,HFpEF涉及慢性炎症,并与代谢障碍有关.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与HFpEF共享病理生理路径,使患者管理复杂化.
研究的目的:
- 探索HFpEF和MASLD之间的复杂相互作用.
- 对患有这两种疾病的患者,审查当前和新兴的管理策略.
- 强调综合代谢和心血管护理的需要.
主要方法:
- 对HFpEF,MASLD及其共同的代谢基础研究的文献综述.
- 对针对共享途径的药理干预措施的分析.
- 对以患者为中心的综合护理模式的证据综合.
主要成果:
- -葡萄糖共运输体2 (SGLT2) 抑制剂在控制高血压和MASLD方面都表现出有效性.
- 葡萄糖类-1受体激动剂 (GLP-1RA) 显示出希望,特别是在MASLD,并且正在对HFpEF进行研究.
- 共享的代谢病理生理学需要统一的治疗方法.
结论:
- 综合代谢和心血管保健对于优化伴随性HFpEF和MASLD患者的治疗结果至关重要.
- 准代谢功能障碍对于管理HFpEF至关重要.
- 解决代谢健康的全球挑战对于心血管和肝脏疾病管理至关重要.
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