健身和运动对大脑年龄的影响:一项随机临床试验
Lu Wan1, Cristina Molina-Hidalgo1, Mary E Crisafio2
1AdventHealth Research Institute, Neuroscience Institute, Orlando, Florida.
medRxiv : the preprint server for health sciences
|March 10, 2025
概括
定期有氧运动可以减少大脑预测年龄差异 (大脑-PAD) 在成年人. 这项为期12个月的研究发现,运动改善了心肺呼吸能力,但确切的机制尚不清楚.
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 衰老研究研究 衰老研究
背景情况:
- 大脑衰老是一个日益关注的问题,与生活方式因素的潜在联系.
- 心血管健康 (CRF) 可能在认知健康和大脑结构中发挥作用.
- 了解运动等干预措施如何影响大脑年龄对于预防性健康策略至关重要.
研究的目的:
- 研究12个月的有氧运动计划对健康成年人大脑预测年龄差异 (大脑-PAD) 的影响.
- 探索心肺呼吸能力 (CRF) 作为运动诱导的大脑年龄变化的潜在媒介.
- 检查其他生理因素 (身体组成,血压,BDNF) 作为潜在的调解者.
主要方法:
- 一个为期12个月的单盲随机临床试验,涉及130名健康成年人 (年龄26-58岁).
- 参与者被分配到中度至强度有氧运动组 (150分钟/周) 或常规护理对照组.
- 大脑PAD和CRF (VO2峰值) 在基线和12个月后被评估.
主要成果:
- 与对照组相比,有氧运动组表现出大脑PAD显著减少.
- 在运动组中,心肺呼吸能力 (VO2峰值) 显著改善.
- 没有观察到身体组成,血压或来自大脑的神经营养因子水平的显著变化.
- 拟议的调解途径在统计学上没有显著性.
结论:
- 十二个月的中度至强度的有氧运动有效地减少了早期到中年成人的大脑PAD.
- 虽然运动可以改善CRF,但调解减少大脑PAD的特定生物途径需要进一步调查.
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