加快生物衰老与结直肠癌之间的关联:一个横截面研究
Sai Wang1, Keyu Wang2, Xiu Wang3
1Department of Thoracic Surgery, Jining Third People's Hospital (Yanzhou District People's Hospital of Jining City), Jining, China.
Frontiers in medicine
|March 10, 2025
概括
生物衰老,以表型年龄 (PhenoAge) 衡量,与更高的结直肠癌 (CRC) 患病率有关,特别是在老年人中. 这突显了生物年龄作为CRC风险的关键因素.
科学领域:
- 老年学是指老年学的学科.
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 生物年龄 (BA) 提供了一个比时间年龄更精确的衰老指标,对于理解与年龄相关的疾病至关重要.
- 生物衰老标志物与结直肠癌 (CRC) 风险之间的联系尚未被探索.
- 研究BA在CRC中的作用可以揭示有关疾病病因和预防的新见解.
研究的目的:
- 调查生物年龄指标与结直肠癌患病率之间的关联.
- 为了确定生物年龄测量是否能够预测CRC风险,而不依赖于时间年龄.
- 为了探索这些协会在不同的人口统计学子组.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 使用克莱梅拉-杜巴尔方法量化生物年龄 (KDMAge) 和基于13个临床生物标志物的表型年龄 (PhenoAge).
- 采用加权基平方测试和多变量逻辑回归来分析生物年龄四分位数的CRC患病率.
主要成果:
- 在越来越多的年代年龄,KDMAge和PhenoAge四分位数中观察到CRC患病率的显著上升趋势.
- 加快的代与较高的CRC患病率显著相关 (OR = 1.767,P = 0.002).
- 这种关联在65岁以上的个体中尤为明显 (OR = 1.655,P = 0.008).
结论:
- 生物衰老标志物与两性结直肠癌患病率积极相关.
- 现型年龄加速是CRC的重要预测因素,特别是在老年人群中.
- 这些发现强调了生物衰老在CRC风险评估中的重要性.
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