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Updated: May 23, 2025

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

在FDG PET-CT上的类固醇诱导的活性白色脂肪组织

Ashique Rehman¹, Tejasvini Singhal¹, Parneet Singh¹

¹Department of Nuclear Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

|March 10, 2025

概括

皮质类固醇可以增加-18D-葡萄糖 (FDG) 在白色脂肪组织 (WAT) 的吸收,这通常显示最小的吸收. 这一案例突出显示了WAT中FDG吸收的增加,这是由于免疫复合体介导的球腺炎的高剂量皮质类固醇治疗.

科学领域:

核医学就是核医学.
内分泌学在内分泌学.
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

白色脂肪组织 (WAT) 通常表现出最小的葡萄糖代谢.
-18D葡萄糖 (FDG) 的吸收在WAT中通常是可以忽略不计的.
已知皮质类固醇会影响FDG生物分布.

研究的目的:

描述一个不寻常的FDG吸收在WAT中增加的情况.
为了将这一发现与高剂量皮质类固醇治疗相关联.
在临床环境中研究皮质类固醇对FDG在WAT中吸收的影响.

主要方法:

一个患有免疫复合体介导的质膜炎的患者的病例报告.
使用高剂量的皮质类固醇治疗.
使用FDG进行正子发射断层扫描 (PET) 影像成像.

主要成果:

患者在WAT中显示了扩散性增加的FDG吸收.
这种增加的摄入量是继高剂量皮质类固醇治疗后观察到的.
这些发现表明,皮质类固醇诱导的FDG在WAT中的生物分布发生了改变.

结论:

高剂量的皮质类固醇治疗可以导致WAT中FDG吸收的显著增加.
这种现象应该在解释FDGPET扫描在皮质类固醇患者的解释中考虑.
改变WAT代谢和FDG吸收可能是皮质类固醇治疗的重要副作用.

关键词:

皮层类固醇的皮层.-18 D-葡萄糖正子辐射断层扫描计算机断层扫描这是白色脂肪组织.

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