数字比率作为牙损的预测:对2D:4D关系的研究
M Ishwarya1, Vasanthakumari Ananthan1, Selvabalaji Arumugam1
1Department of Pediatric and Preventive Dentistry, Adhiparasakthi Dental College and Hospital, The Tamil Nadu Dr.M.G.R Medical University, Melmaruvathur, Tamil Nadu, India.
Journal of pharmacy & bioallied sciences
|March 10, 2025
概括
低2D:4D比率的儿童,表明产前更高的雄激素暴露,显示牙损风险增加. 这一比率可以预测儿科人口的虫易感性.
科学领域:
- 儿科牙科 儿科牙科
- 内分泌学 在内分泌学.
- 人类生物学 人类生物学
背景情况:
- 2D:4D数字比率是产前荷尔蒙暴露的公认指标,特别是雄激素.
- 牙损仍然是全世界儿童的重大公共卫生问题.
- 了解影响脏病风险的因素对于制定有效的预防策略至关重要.
研究的目的:
- 调查2D:4D数字比率与5-12岁儿童牙损伤风险之间的关联.
- 探索2D:4D比率作为产前激素暴露的潜在生物标志物及其与虫易感性的联系.
- 检查2D:4D比率的性别特异性差异及其与脏病患病率的关系.
主要方法:
- 一项涉及250名5至12岁儿童的横截面研究.
- 测量2D:4D数字比率使用Vernier标尺.
- 使用腐烂,缺失和填充牙 (DMFT/deft) 指数和统计分析 (Chi-square测试) 评估牙损伤.
主要成果:
- 在2D:4D比率低 (<1) 的儿童中,观察到牙损伤的患病率显著更高,这表明产前雄激素水平升高.
- 在2D:4D比率<1的儿童中,83.67%的儿童有较高的虫指数,而在2D:4D比率≥1.1的儿童中,这一比例为31.07%.
- 男性的平均2D:4D比率低于女性,这表明性别特异性的荷尔蒙影响了数字发育和潜在的虫风险.
结论:
- 2D:4D数字比率可以作为儿童牙风险的预测标记.
- 产前激素暴露,如2D:4D比率所示,似乎在牙变的发展中起作用.
- 需要进一步的研究来阐明将数字比率,荷尔蒙影响和儿科牙健康联系在一起的机制.
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