在2型糖尿病患有视网膜病变和脏病变的患者中,宁血管素阿尔多斯特系统基因多态性
Vaishali S Pawar1, Kailas D Datkhile2, Ajit V Sontakke1
1Department of Biochemistry, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India.
Journal of pharmacy & bioallied sciences
|March 10, 2025
概括
氨酸- ангиотензин- алдостерон系统 (RAAS) 基因的多态性,特别是ACE和AGT,与2型糖尿病 (T2DM) 患者的糖尿病脏病和视网膜病变有关. 这些遗传变异增加了发展这些严重T2DM并发症的风险.
科学领域:
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 2型糖尿病 (T2DM) 可以导致严重的并发症,如糖尿病病 (DN) 和糖尿病视网膜病变 (DR).
- 氨酸- ангиотензин- алдостерон系统 (RAAS) 在血压调节中发挥作用,并与DN有关.
- 在T2DM患者中,RAAS基因多态性与DN和DR的联合关联存在有限的研究.
研究的目的:
- 研究特定RAAS基因多态化与T2DM患者DN和DR的发展之间的关联.
- 探索血管素 (AGT) Met235Thr和血管素转化酶 (ACE) 插入/删除 (ins/del) 多态度所带来的风险.
主要方法:
- 一项涉及125名DN和125名DR的T2DM患者的横截面研究,与没有这些并发症的T2DM患者进行了比较.
- 在ACE (ins/del) 和AGT (Met235Thr) 基因中使用聚合酶链反应 (PCR) 分析单核酸多态 (SNPs).
- 使用SPSS软件进行的统计分析,以确定关联和赔率比率 (OR).
主要成果:
- 患有DN的患者表现出明显更高的血压,血清尿素和肌素水平.
- 在DR和DN组中,ACE SNP的DD基因型显著更普遍 (OR:分别为2.87和2.36).
- 在DN患者中,AGT Met235Thr SNP的CC和TC基因型显著增加,而DR患者的TC基因型则增加.
结论:
- 在T2DM患者中,ACE ins/del和AGT Met235Thr基因多态性与患糖尿病脏病和视网膜病变的风险增加有关.
- 这些发现突出了RAAS基因变异在T2DM相关微血管并发症的发病过程中的作用.
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