队列概况:非传染性疾病的TRACING病因学 (趋势):理由,进展和前景
Hui-Ying Ren1,2, Ying Lv3, Bei-Ning Ma4,5
1Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing, 210009 China.
Phenomics (Cham, Switzerland)
|March 10, 2025
概括
中国的TREND队列研究正在建立一个生物库,在20,000个人中深入表型非传染性疾病 (NCD). 这项研究旨在发现改善诊断和治疗的分子洞察力.
科学领域:
- 流行病学 流行病学
- 基因组学就是基因组学.
- 蛋白质组学是指蛋白质组学.
- 代谢学 代谢学 代谢学
- 微生物组研究的研究.
- 这是生物银行.
背景情况:
- 非传染性疾病 (NCDs) 构成了全球重大健康负担.
- 了解非传染性疾病的复杂病因需要进行大规模的纵向研究.
- 非传染性疾病的TRACING病因学 (TREND) 队列是为了满足这一需求而建立的.
研究的目的:
- 对广泛的非传染性疾病进行全面的分子表征和深度表型.
- 提供对非传染性疾病的机械洞察力,具有潜在的诊断,预后和治疗影响.
- 为长期的NCD研究建立一个潜在的纵向队列和生物库.
主要方法:
- 预期纵向研究设计,每年随访30年.
- 从中国马安山招募了2万名18岁以上的参与者.
- 收集广泛的数据,包括社会经济,病史,生活方式,临床测量和多omics数据 (基因组,蛋白质组,代谢组,微生物组).
- 建立一个生物银行,将生物样本 (血液,尿液,便) 储存在-80°C的温度下.
主要成果:
- 在第一阶段初步招募3360名参与者.
- 分层年龄分布 (18-45,45-55,55-65,≥65岁) 和受控的性别分布.
- 基线数据收集包括各种健康和生活方式因素.
- 综合的分子分析,包括多个omics分析.
结论:
- 趋势队列为研究非传染性疾病的病因提供了宝贵的资源.
- 深度表型和分子特征将为疾病机制提供关键的见解.
- 这项研究旨在推进非传染性疾病的诊断,预后和治疗策略.
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