高近视的老年人角膜内皮的特征
Yinglei Zhang1,2,3,4, Shaohua Zhang1,2,3,4, Keke Zhang1,2,3,4
1Eye Institute, Eye and Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University, 83 Fenyang Rd, Shanghai, 200031 People's Republic of China.
Phenomics (Cham, Switzerland)
|March 10, 2025
概括
高近视的老年人表现出改变的角膜内皮细胞,较长的轴长与细胞密度增加和形状变化有关. 高近视也与富氏内皮角膜缩症 (FECD) 的更高的患病率和严重程度相关.
科学领域:
- 眼科医生 眼科 眼科
- 角质科学 角质科学
- 老年医学 老年医学
背景情况:
- 高近视是各种眼部病理的重要危险因素.
- 角膜内皮细胞在保持角膜透明度和健康方面发挥着至关重要的作用.
- 角膜内皮的与年龄相关的变化已得到充分证实,但它们与高近视的相互作用需要进一步研究.
研究的目的:
- 在高近视的老年人中调查角膜内皮细胞特征.
- 为了比较内皮细胞密度,形态学和高近视和对照眼睛之间的福克斯内皮角膜变 (FECD) 患病率.
- 探索轴长和角膜内皮参数之间的相关性.
主要方法:
- 一项涉及1065名老年患者的横截面研究 (549名高近视,516名对照).
- 使用非接触型光镜显微镜来评估角膜内皮特征.
- 裂灯和共聚焦显微镜用于FECD确认.
主要成果:
- 与对照人群相比,高度近视的眼睛显示出明显更高的中央内皮细胞密度 (ECD) 和变化系数 (CV),以及较低的平均细胞面积 (AVG) 和六角性 (HEX).
- 较长的轴长 (AL) 与ECD和CV正相关,与AVG和HEX负相关.
- 在高度近视的眼睛 (4.92%) 中,FECD的患病率高于对照组 (3.29%),观察到的病例更为晚期.
结论:
- 老年患者的轴长度增加与较高的角膜内皮细胞密度,多形态和多重性有关.
- 高度近视的眼睛表现出更高的患病率和严重程度的Fuchs内皮角膜缩症.
- 这些发现突出了高近视对老年人口角膜内皮质健康的影响.
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