截肢与肢体救生手术作为儿童骨肉瘤的治疗方法:对生存,功能和生活质量的比较研究
Sara S Vale1, Rui Castro2, Alexandra Andrade3
1Pediatrics, Unidade Local de Saúde Região de Leiria Entidade Pública Empresarial (EPE), Leiria, PRT.
Cureus
|March 10, 2025
概括
与截肢相比,肢体救生手术为儿科骨肉瘤患者提供了更好的功能结果和生活质量. 然而,整体生存仍然是一个重大挑战,特别是在资源有限的环境中.
科学领域:
- 儿科瘤学 儿科瘤学
- 整形外科手术 整形外科手术
- 医学成果研究研究成果
背景情况:
- 儿科附骨肉瘤 (骨肉瘤,尤文肉瘤) 是一种罕见的,具有侵略性的癌症,影响生存和生活质量.
- 治疗选择包括肢体救生手术 (LSS) 和截肢 (AMP),对结果的比较数据有限.
研究的目的:
- 为了比较儿科附骨肉瘤的LSS和AMP之间的功能结果,生活质量 (QoL) 和存活率.
- 确定影响该患者群体结果的因素.
主要方法:
- 在2000-2021年期间接受治疗的62名儿科患者的回顾性队列研究.
- 使用多伦多极端救援得分 (TESS) 和使用MOS SF-36v2.2.使用QoL的功能性结果的评估.
- 通过手术方法分层 (LSS与AMP) 和对生存数据的分析.
主要成果:
- 总体而言,五年生存率为38%. 较低的生存率与转移性疾病,较大的瘤 (>8厘米) 和AMP相关.
- 在LSS (59.7%的病例) 中,功能平均得分 (88.4%) 比AMP (79%) 高.
- LSS患者报告了更好的QOL,特别是在身体和情绪领域. 来自葡萄牙语非洲国家的患者面临着差异.
结论:
- 肢体救生手术提供优越的功能结果和QoL与截肢相比,用于儿科骨肉瘤.
- 生存仍然是一个挑战,特别是对于来自资源有限环境的患者来说,突出了差异.
- 早期诊断,改善医疗保健准入和进一步的研究对于更好的治疗结果至关重要.
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