与COVID-19疫苗接种相关的心脏并发症:对队列研究的系统审查
Indrajit Banerjee1, Jared Robinson2, Indraneel Banerjee3
1Pharmacology, Sir Seewoosagur Ramgoolam Medical College, Belle Rive, MUS.
Cureus
|March 10, 2025
概括
接种COVID-19疫苗,特别是基于mRNA的疫苗,很少会导致心肌炎或心周炎. 年龄在16-39岁的年轻男性的风险更高,尤其是在第二次接种疫苗后,需要加强监测. 总体而言,疫苗的好处远远超过了这些最小的风险.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19大流行,全球疫苗接种运动开始,已经接种了超过136.4亿剂疫苗.
- 心脏不良事件,包括心肌炎和心周炎疫苗接种后,一直是重要的研究重点.
- 现有的审查通常依赖于病例报告;这项研究综合了队列研究的数据.
研究的目的:
- 系统地审查关于COVID-19疫苗接种后心脏不良影响风险的队列研究.
- 为了确定这些不良事件的高风险的特定患者群体.
主要方法:
- 在PubMed,Cochrane CENTRAL,Trip数据库和谷歌学者中进行了全面的文献搜索.
- 包括的研究是2020年12月1日至2024年12月31日期间发表的队列研究.
- 在选了18,272篇文章后,有4项研究符合纳入标准.
主要成果:
- 基于mRNA的COVID-19疫苗与心肌炎和心周炎的最小风险有关.
- 年龄在16-39岁之间的年轻男性表现出明显增加的风险,特别是在接种第二剂疫苗后.
- 这些心脏事件的发生率很少见,但在特定的人口统计数据中需要注意.
结论:
- 虽然很少见,但mRNA COVID-19疫苗可以引起心肌炎或心周炎,在接受第二剂的年轻男性中风险更高.
- 对于16-39岁的个体,建议加强疫苗接种后的监测.
- 接种COVID-19疫苗的实质性好处继续超过心脏不良影响的最小风险.
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