Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antimicrobial Proteins01:23

Antimicrobial Proteins

857
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
857
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

6.3K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

K<sub>3</sub>Yb<sub>2</sub>(BO<sub>3</sub>)<sub>3</sub> and Rb<sub>3</sub>Yb<sub>2</sub>(BO<sub>3</sub>)<sub>3</sub>: Two Rare-Earth Borate Ultraviolet Nonlinear Optical Crystals.

Inorganic chemistry·2026
Same author

Cardiac glycosides in patients with heart failure and reduced ejection fraction: a systematic review and meta-analysis.

Frontiers in cardiovascular medicine·2026
Same author

Unit Symmetry-Breaking and Layered Linear Ordering Enabling Superior Short-Wave Ultraviolet Birefringent Crystal.

Angewandte Chemie (International ed. in English)·2026
Same author

Noncoding RNA family classification based on multifeature fusion and convolutional block attention residual network.

Briefings in bioinformatics·2025
Same author

KF·[SO<sub>2</sub>(NH<sub>2</sub>)<sub>2</sub>]: the First Deep-Ultraviolet Transparent Sulfonamide Fluoride Nonlinear Optical Crystal with Novel Cairo Pentagonal Structure.

Angewandte Chemie (International ed. in English)·2025
Same author

Strongly Polar [H<sub>2</sub>PO<sub>3</sub>]<sup>-</sup> Induced π-Conjugated Group Arrangement for Balanced UV Nonlinear Optical Performance.

Inorganic chemistry·2025

相关实验视频

Updated: May 23, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.4K

iAMP-CRA:使用卷积循环神经网络与自我注意力识别抗菌.

Jingyao Lu1, Yang He1, Guosheng Han1

  • 1School of Mathematics and Computational Science, Xiangtan University, Yuhu Street, Xiangtan, 411105 Hunan China.

Health information science and systems
|March 10, 2025
PubMed
概括

抗微生物 (AMP) 为传统抗生素提供了一个有希望的替代品. 一个新的深度学习模型,iAMP-CRA,从大量的蛋白质数据中有效地识别潜在的AMP,有助于发现新型抗菌剂.

科学领域:

  • 计算生物学是一种计算生物学.
  • 生物化学 生物化学
  • 传染病 传染病 传染病

背景情况:

  • 抗微生物 (AMP) 是天生的免疫系统的关键组成部分,具有固有的抗菌特性.
  • 抗生素耐药性的增加需要探索替代治疗策略,将AMP定位为非常有前途的候选人.
  • 深度学习方法通过分析广泛的蛋白质序列数据集,为加速发现新型AMP提供了强大的工具.

研究的目的:

  • 开发一个灵活和可解释的深度学习模型,称为iAMP-CRA,用于有效选和识别抗菌.
  • 利用具有自我注意机制的卷积循环神经网络来增强AMP分类.
  • 整合多种序列编码策略和特征提取模块,以实现全面的表示学习.

主要方法:

  • 设计了使用卷积循环神经网络和自我注意的iAMP-CRA模型.
  • 采用各种序列嵌入编码来捕获主要结构和进化信息.
  • 集成多个特征描述器,使用机器学习模型进行评估,以增强特征表示.
  • 利用注意力机制来融合互补信息并创建用于分类的统一特征表示.

主要成果:

  • iAMP-CRA模型在基准数据集上展示了强大的学习能力.
  • 该模型成功地学习了高效的序列编码,并适应性地结合了异质特征.
关键词:
抗微生物是一种抗微生物.注意力机制注意力机制深度学习是一种深度学习.功能融合的特点是:机器学习 机器学习

更多相关视频

DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning
04:17

DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning

Published on: May 10, 2024

597
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

12.4K

相关实验视频

Last Updated: May 23, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

12.4K
DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning
04:17

DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning

Published on: May 10, 2024

597
Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

12.4K
  • 在独立的测试套件上达到0.919的高精度,超越或匹配最先进的方法.

    • 结论:

    • 该iAMP-CRA模型提供了一个有效的深度学习框架,用于发现新型抗微生物.
    • 该模型的可解释性和灵活性有助于其在识别有前途的AMP候选人的实用性.
    • 这种方法具有很大的潜力,可以通过促进新抗菌剂的开发来应对常规抗生素耐药性的挑战.