在北克的慢性疼痛患者中解开过度多药模式:一项纵向研究
Gwenaelle De Clifford-Faugère1,2, Hermine Lore Nguena Nguefack1,2, Nancy Ménard2
1Département des Sciences de la Santé, Université du Québec en Abitibi-Témiscamingue (UQAT), Rouyn-Noranda, QC, Canada.
Frontiers in pain research (Lausanne, Switzerland)
|March 10, 2025
概括
过度多药 (≥10种药物) 在慢性疼痛患者中很常见. 这项研究确定了明显的长期药物使用模式和相关的风险因素,突出了个性化干预的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 过度多药 (同时使用≥10种药物) 在慢性疼痛患者中很普遍.
- 了解随着时间的推移和个体之间的多药学变化对于有效管理至关重要.
研究的目的:
- 描述和确定与慢性疼痛的成年人过度多药的不同轨迹相关的因素.
主要方法:
- 一项追溯纵向研究利用了加拿大卫生行政数据 (2007-2016) 和调查.
- 基于小组的轨迹建模分析了9156名患有慢性疼痛的成年人一年内每月过度多药状态.
- 多变量多项回归确定了与特定多药学轨迹相关的因素.
主要成果:
- 确定了四种不同的轨迹:没有过度多药 (74.8%),有时 (8.6%),经常 (6.1%),总是 (10.5%).
- 与"总是过度多药"相关的因素包括年龄较大,加拿大出生,收入较低,并发病率较高,疼痛严重程度较高,功能限制,特定疼痛状况,健康感知较差和医疗保健利用率较高.
- 吸食阿片类药物/二二类药物的使用,较低的体力活动,以及更多的处方者也预测了持续的过度多药性.
结论:
- 在患有慢性疼痛的成年人中,存在过度多药的明显轨迹.
- 关键的社会人口统计学,临床和医疗保健利用因素与持续的多药学有关.
- 需要量身定制的干预措施,才能在这个人群中有效地治疗药物.
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