癌症患者与免疫相关的严重不良事件相关的危险因素:范围审查
Zhenzhen Su1,2, Liyan Zhang2, Xuemin Lian1,3
1School of Nursing, Peking University, Beijing, China.
Asia-Pacific journal of oncology nursing
|March 10, 2025
概括
在接受免疫检查点抑制剂 (ICI) 的癌症患者中,确定严重免疫相关不良事件 (ir-SAE) 的风险因素对于患者安全至关重要. 本综述综合了与ir-SAE相关的人口,疾病和实验室因素.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床药理学 临床药理学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 然而,与免疫相关的严重不良事件 (ir-SAE) 引发了严重的安全问题.
- 了解ir-SAE的风险因素对于积极的患者管理至关重要.
研究的目的:
- 系统地识别和综合与治疗ICI的癌症患者中与ir-SAE相关的风险因素.
- 提供关于ir-SAE风险因素的当前知识的全面概述.
主要方法:
- 按照乔安娜·布里格斯研究所的指导方针进行全面的范围审查.
- 在多个国际数据库中进行广泛的文献搜索,直到2024年1月.
- 数据的提取和综合由两个独立的审稿人.
主要成果:
- 包括41项研究,包括各种研究设计 (病例控制,队列,元分析).
- 鉴定到的风险因素分为三个主要类别:人口因素,与疾病有关的因素和与实验室检查有关的因素.
- 这些类别内的各种各样的特定因素有助于ir-SAE.
结论:
- 在接受ICI治疗的癌症患者中,多种因素增加了ir-SAE的风险.
- 在这些风险因素上教育瘤护士可以改善早期识别和管理.
- 需要进一步的研究来澄清具有高预测价值的ir-SAE风险因素.
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