奇胺与DCAG结合使用或不使用威尼托克拉克斯治疗复发性/耐火性急性髓性白血病
Qingyang Liu1,2, Xiawei Zhang1,2, Lei Lv1,2
1State Key Laboratory of Experimental Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Cancer medicine
|March 10, 2025
概括
将venetoclax添加到CDCAG疗法中,显著改善了复发性和耐药性急性髓性白血病 (R/R AML) 患者的治疗结果. 这种组合疗法显示出更高的反应率和更好的生存率,提供了一个有前途的新治疗方案.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 对于复发性和耐药性急性髓性白血病 (R/RAML) 的患者,存在有限的治疗选择.
- 新型治疗策略对于改善R/RAML患者的治疗结果至关重要.
研究的目的:
- 评估CDCAG-VEN疗法 (chidamide,去甲基化药物,cytarabine,aclacinomycin,G-CSF加venetoclax) 在R/RAML患者中的疗效和安全性.
- 为了比较CDCAG-VEN疗法与历史的CDCAG疗法作为对照.
主要方法:
- 一个单一的中心,第一阶段的前性研究进行.
- 30名患者接受了CDCAG治疗方案,而22名患者接受了CDCAG-VEN治疗方案.
- 两组的有效性和安全性结果进行了比较.
主要成果:
- 与CDCAG-VEN组相比,CDCAG-VEN组的整体应答率 (78.6%与45.5%) 和1年整体存活率 (63.3%与35.1%) 显著提高.
- 没有进展的生存率 (76.7%与36.0%) 和响应的持续时间也与CDCAG-VEN.显著改善.
- 不良事件是可比的,特别是在CDCAG-VEN组中血栓形成的发病率明显较低.
结论:
- 与CDCAG疗法相结合的Venetoclax是一种有效和安全的R/RAML治疗方法.
- 这种组合可以快速识别化学敏感患者,并诱导可测量的残留病阴性缓解.
- CDCAG-VEN疗法代表了R/R AML治疗的重大进展.
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