2021年主要慢性肝病的全球负担
Gong Feng1,2, Yusuf Yilmaz3, Luca Valenti4,5
1Xi'an Medical University, Xi'an, China.
概括
在全球范围内,慢性肝病的负担是显著的. 虽然乙型肝炎和型肝炎的患病率下降,但代谢功能障碍相关的肝病 (MASLD) 和肝硬化增加,需要针对性的公共卫生干预措施.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 肝脏疾病研究 肝脏疾病研究
背景情况:
- 利用全球疾病负担数据 (2010-2021) 来分析慢性肝病的趋势.
- 包括B型肝炎,C型肝炎,与代谢功能障碍相关的肝病 (MASLD),肝硬化和其他慢性肝病.
- 检查了点患病率,年均发病率和残疾生活年 (YLDs).
研究的目的:
- 分析主要慢性肝病的全球发病率和趋势.
- 为了在不同地区,国家和社会人口指数 (SDI) 水平上比较流行率,发病率和YLDs.
- 为公共卫生战略和用于肝病管理的资源配置提供信息.
主要方法:
- 每10万人口就业年龄标准化率.
- 在地理区域和社会人口统计指数 (SDI) 中比较趋势.
- 趋势表达为百分比变化 (PC) 与不确定性间隔 (UI).
主要成果:
- 2021年,MASLD和肝硬化患病率高于乙型肝炎和C型肝炎.
- 从2010-2021年,乙型肝炎和型肝炎的流行率和发病率显著下降.
- MASLD和肝硬化患病率和发病率呈现上升,MASLD在中度SDI时达到顶峰.
结论:
- 慢性肝病的全球负担仍然很大.
- B型肝炎和C型肝炎呈现下降趋势,而MASLD和肝硬化正在增加.
- 有针对性的公共卫生战略和资源配置对于管理日益增加的慢性肝病负担至关重要.
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