在急性肝衰竭中未能救援:一个多中心队列研究
Filipe S Cardoso1, William M Lee2, Constantine J Karvellas3
1Departments of Hepatology and Critical Care, Curry Cabral Hospital, Nova Medical School, Lisbon, Portugal.
概括
没有救援,手术并发症的护理质量的衡量标准,在急性肝功能衰竭 (ALF) 中了解得很少. 这项研究发现,ALF患者的早期医学并发症显著增加了无移植死亡率,强调了需要改进的管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 关键护理医学 关键护理医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 救助失败 (FTR) 是手术并发症的质量指标,但在急性肝衰竭 (ALF) 等初级医疗条件中没有得到充分研究.
- 在ALF患者中评估FTR对于理解和改善这一脆弱人群的结果至关重要.
研究的目的:
- 调查急性肝衰竭 (ALF) 患者的救助失败的概念.
- 确定早期医学并发症与ALF患者21天无移植死亡率之间的关联.
主要方法:
- 使用美国ALF研究小组 (USALFSG) 注册表 (2010-2016) 的回顾性多中心队列研究 (2010-2016).
- 计算了12种医学并发症的FTR率,并分析了它们与21天无移植死亡率的关联.
- 根据年龄,性别,病因和国际正常化比率进行调整.
主要成果:
- 在665名ALF患者中,69.3%的患者在第一天至少有一次医疗并发症.
- 12个并发症的整体FTR率为32.8%.
- 在第一天的每一个额外的并发症都将21天的无移植死亡率的几率提高38% (aOR 1.38).
结论:
- 无法救援的概念与急性肝衰竭 (ALF) 有关,并突出了与早期医疗并发症相关的重大风险.
- 改善ALF患者医疗并发症的预防,早期发现和及时管理对于降低死亡率至关重要.
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