Syndecan-1作为高风险儿科心脏手术后液体过载的生物标志物:试点研究
Matthew A Solomon1,2, David S Hains2,3, Andrew L Schwaderer2,3
1Division of Pediatric Critical Care, Riley Hospital for Children, Indianapolis, IN.
概括
血Syndecan-1 (SD1) 水平可以帮助识别复杂心脏手术后儿童的液体过载 (FO). 升高的SD1表明内皮糖损伤,并与更糟糕的结果有关,表明其作为FO生物标志物的潜力.
科学领域:
- 心血管外科心血管外科
- 儿科重症监护 儿科重症监护
- 生物标志物发现发现
背景情况:
- 流体过载 (FO) 是儿童心脏手术后的常见并发症,其中包括心肺旁路 (CPB).
- FO与患者的不良结果有关.
- 内皮糖体损伤,由syndecan-1 (SD1) 水平表明,可能在FO中发挥作用.
研究的目的:
- 为了研究血中syndecan-1 (SD1) 度和流体过载 (FO) 之间的关系.
- 评估SD1作为FO的潜在生物标志物,用于接受CPB心脏手术的儿科患者.
主要方法:
- 在儿科心脏重症监护病房进行的前性观察试点研究.
- 招募了15名接受CPB高风险心脏手术的儿科患者.
- 在手术前和手术后测量了血SD1度,并将其与手术后几天的液体平衡进行了比较.
主要成果:
- 血SD1水平在术后第一,第二和第三天有效区分流体平衡>=10% (AUROC 0.74-0.88).
- 在术后的前七天内,SD1还区分了峰值液平衡>=10% (AUROC 0.94).
- 较高的三角形SD1显着与>=10%的液体平衡和诸如长时间机械通风等不良事件相关.
结论:
- 血SD1与CPB心脏手术后的儿科患者的液体过载有关.
- 在这种患者群体中,SD1显示为确定FO的生物标志物.
- 需要进一步的研究来探索SD1在治疗儿科心脏手术患者中的临床实用性.
关键词:
心脏外科手术手术的过程.通过心肺绕道术 (cardiopulmonary bypass) 进行心肺绕道术.这是先天的,先天的.葡萄糖糖的性糖质 (glycocalyx) 是一种心脏缺陷 心脏缺陷这就是Syndekan-1的作用.更多相关视频
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