挖掘Epicoccum dendrobii的基因组揭示了各种抗菌天然产品
Anxin Zhang1,2, Xinran Xu1,2, Wen-Bing Yin1,2
1State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China.
Journal of agricultural and food chemistry
|March 10, 2025
概括
埃皮科克木 (Epicoccum dendrobii) 生产出具有抗菌和抗真菌特性的新型化合物. 这些生物活性代谢物显示出农业生物控制应用的潜力.
科学领域:
- 农业科学 农业科学
- 菌类学 菌类学是指菌类学.
- 自然产品化学 自然产品化学
背景情况:
- 埃皮科克 (Epicoccum dendrobii) 是一种以生产生物活性代谢物而闻名的真菌.
- 这些代谢物具有农业应用的潜力,特别是生物控制.
研究的目的:
- 鉴定和描述来自E. dendrobii. 的新生物活性代谢物.
- 研究这些化合物的抗菌和抗真菌活性.
- 阐明特定代谢物的生物合成途径及其在生物控制中的作用.
主要方法:
- 基因组挖掘是为了发现潜在的生物活性化合物.
- 使用NMR和HR-ESI-MS阐明结构.
- 抗菌和抗真菌测定以确定生物活性.
- 原生体转化和基因集群识别 (eda).
主要成果:
- 发现了三种新型的多基基 (epiketides A-C) 和一种新型的天然产品 (epiketide D),以及已知的类似物.
- 化合物1,2和4对Bacillus licheniformis和Pseudomonas aeruginosa表现出中度的抗菌活性.
- 鉴定了负责狄基托皮帕拉生物合成的EDA基因集群.
- 野生类型的E. dendrobii显示出 Botrytis cinerea 的显著抑制,一个缺乏 diketopiperazines 的突变体显示出有效性降低.
结论:
- E. dendrobii 是一种具有潜在农业应用的新生物活性代谢物的来源.
- 由E.dendrobii产生的Diketopiperazines在其对植物病原体的抗真菌活性中发挥作用.
- 这项研究支持使用E. dendrobii作为生物控制剂.
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