在COVID-19中变得脆脆:灾难性的多器官性的一个独特案例
Andrew Johnson1, Kathryn Manocchia, Marisa Jacob-Leonce
1From the Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.
The American journal of forensic medicine and pathology
|March 10, 2025
概括
一种罕见的疾病 - - 石灰症 (calciphylaxis) 可能是由COVID-19等非尿素性因素引发的. 这种病例显示严重的全身石灰会影响皮肤和器官,导致致命的结局.
科学领域:
- 血管医学 血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 皮肤病学 皮肤病学
背景情况:
- 石灰 (性尿性动脉病变) 是一种罕见的病理生理学不清楚的疾病,通常与末期病 (ESRD) 和甲状腺功能障碍症有关.
- 虽然通常会影响皮肤,但系统性石灰症涉及皮外器官.
- 新出现的风险因素包括感染,皮质类固醇/华法林使用,糖尿病,自身免疫性疾病和蛋白质C/S缺乏.
研究的目的:
- 为了呈现一个灾难性的系统性化症的案例.
- 突出COVID-19和非尿素性因素在触发石灰症中的潜在作用.
主要方法:
- 一个48岁的女性患有艾滋病毒,胰腺炎和COVID-19的病例报告.
- 临床表现包括腹痛,虚弱,皮肤病变,视力丧失,高血压和急性损伤.
- 尸体解剖证实了广泛的皮肤和内脏,特别是在心脏和肺部.
主要成果:
- 患者的病情迅速恶化,并因病情而死亡.
- 尸体解剖显示了广泛的皮肤化 (>50%的身体表面积) 和广泛的内脏化.
- 心脏和肺部显示了最引人注目的器官参与.
结论:
- 应考虑COVID-19和其他非尿素性因素是系统性石灰症的潜在触发因素.
- 这一案例凸显了系统性化在非尿血病患者中的灾难性潜力.
- 迅速识别和管理非尿素性风险因素至关重要.
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