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化物对肠道微生物群的影响:系统性审查

Momina Yasin^1,2, Fatemeh Vida Zohoori^1,2, Elizabeth Adjoa Kumah³

¹School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom.

Nutrition reviews

|March 10, 2025

概括

系统性化物影响肠道微生物群. 低剂量 (≤2 mg/L NaF) 可能有利于肠道健康,而高剂量 (≥10 mg/L NaF) 可能是有害的,改变微生物的组成和功能.

科学领域:

微生物组研究的研究.
毒理学毒理学毒理学
公共卫生公共卫生

背景情况:

化物是通过影响口腔微生物群和牙重矿化来预防牙损伤而闻名的.
化物对肠道微生物群的系统性影响仍然在很大程度上未被探索.
这项研究解决了关于化物对胃肠道微生物群的影响的知识差距.

研究的目的:

研究系统性化物暴露对肠道微生物群的组成,丰度和功能属性的影响.
分析化物影响的相关基因和代谢调节.
综合目前关于化物对肠道微生物生态系统影响的证据.

主要方法:

在主要的科学数据库 (MEDLINE,科学网,Scopus,PubMed,CINAHL,Embase) 进行了全面的系统文献搜索.
使用Covidence进行了资格查和数据提取,涉及49项选定的研究 (42种动物,4种人类,3种实验室).
两位审查员使用混合方法评估工具独立评估了研究质量.

主要成果:

人类研究表明,在高化物条件下,肠道微生物组成发生了变化,酸性细菌和蛋白质细菌增加,Firmicutes和Bacteroidetes减少.
实验室和动物研究表明,低NaF度 (≤2 mg/L) 可能促进有益的种群,而较高度 (≥10 mg/L) 可能增加不健康的微生物.
在动物研究中,在暴露于高化物剂量 (50-1200 mg/L NaF) 后,观察到Firmicutes与Bacteroidota比率的显著干扰.

结论:

高剂量的系统性化物可能会对人类肠道微生物组产生负面影响.
低化物水平 (≤2 mg/L NaF) 对人类肠道微生物群产生了积极影响.
动物研究表明≥50 mg/L NaF的剂量是不安全的,而≤25 mg/L NaF似乎对肠道微生物群无害.

关键词:

18F-FDG (-18氧葡萄糖) 是一种化合物.动物动物动物动物动物动物脱矿化脱矿化化物化物是什么?我们的肠道微生物群.人类人类人类人类人类人类.重矿化是指重矿化的过程.短链脂肪酸短链脂肪酸

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