更多的年轻,西方患者也会患上肝细胞癌吗?
Daniel S Cheah1, Kathryn Tsai1, Fumihiro Kawano2,3
1Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Annals of surgical oncology
|March 10, 2025
概括
早期发病的肝细胞癌 (eHCC) 发病率正在下降,与一般癌症趋势相反. 尽管疾病较晚,但eHCC患者与典型发病的HCC (tHCC) 相比,手术结果有所改善.
科学领域:
- 在瘤学瘤学.
- 肝胆道手术 肝胆道手术
- 癌症流行病学 癌症流行病学
背景情况:
- 早期癌症的发病率上升与早期肝细胞癌 (eHCC) 的不清楚趋势形成鲜明对比.
- 缺乏对eHCC的明确定义,因此需要确定年龄截止值.
- 这项研究调查了eHCC发病率,临床特征,手术结果和生存率与典型发病的HCC (tHCC) 相比.
研究的目的:
- 建立一个基于证据的年龄截止值来定义早期发病的肝细胞癌 (eHCC).
- 分析eHCC发病率的趋势,并比较临床表现,手术结果和典型发病型HCC (tHCC) 的存活率.
主要方法:
- 利用国家癌症数据库 (2010-2021) 对肝细胞癌 (HCC) 患者.
- 在统计上定义了eHCC (<50岁) 和tHCC (≥50岁).
- 员工倾向得分匹配,多变量危险比率和卡普兰-梅尔生存分析.
主要成果:
- 在207,653名HCC患者中确定了10,128例 (4.88%) 的eHCC病例;eHCC发病率从7.50%降至3.83% (2010-2021年).
- 在所有阶段,eHCC显示出更高度,同步转移和节点参与,但显示出更好的生存率 (p < 0.001).
- 在匹配后,eHCC对I,II和T1-T3阶段的瘤有更好的结果,但不是T4. 更糟糕的生存预测因素包括tHCC,缺乏保险和更高的TNM阶段.
结论:
- 确定了eHCC的新年限,尽管癌症的早期发病趋势普遍存在,但其发病率正在下降.
- 与tHCC相比,eHCC患者患有更晚期的癌症,但获得更好的外科治疗结果.
- 患有I,II或T1-T3阶段eHCC的年轻患者在切除后经历了良好的结果.
更多相关视频
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.0K
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
329
相关概念视频
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
01:26Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...