整合多omics数据,以揭示宿主微生物群相互作用在炎症性肠病中的行为体
Fengyuan Su1,2, Meng Su3, Wenting Wei4
1Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Gut microbes
|March 10, 2025
概括
本综述探讨了肠道微生物群失衡或失生症如何导致炎症性肠病 (IBD) 的病原性. 它强调了"互动组"概念和多组学方法,以了解IBD中的宿主-微生物相互作用.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 系统生物学 系统生物学
背景情况:
- 人们越来越认识到肠道微生物群在炎症性肠病 (IBD) 中的作用.
- 由于生态系统的复杂性,IBD中宿主-微生物相互作用的精确机制在很大程度上仍未定义.
研究的目的:
- 使用"互动组"概念,系统地总结肠道失生症在IBD病变的参与.
- 为研究IBD中宿主微生物群相互作用的机制,多组学方法,队列资源和计算方法提供最新的概述.
主要方法:
- 审查有关肠道微生物群和IBD的现有文献.
- 介绍和应用"互动原子"概念来分析失生症.
- 讨论高通量多omics方法和计算方法的讨论.
主要成果:
- 肠道失生症通过微生物组成,功能,基因组结构,转录活性和下游代谢物的变化,导致IBD.
- 多omics数据集成对于破译IBD中复杂的宿主-微生物群交叉对话至关重要.
结论:
- 了解肠道微生物群互动组是揭开IBD病原学的关键.
- 未来的研究应该专注于整合多学科数据,以推进IBD治疗策略.
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