在怀孕期间的家族性高胆固醇血症
Fahad Alnouri1, Frederick J Raal2
1Head of Cardiovascular Prevention Unit, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia.
Current opinion in lipidology
|March 10, 2025
概括
在怀孕期间管理家族性高胆固醇血症 (FH) 需要平衡母亲的LDL胆固醇控制与胎儿安全. 怀孕期间同卵性FH (HoFH) 缺乏具体指导方针,需要进一步研究和协调护理.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 产科 产科 产科 产科 产科
背景情况:
- 家族性高胆固醇血症 (FH) 在怀孕期间带来了独特的挑战,特别是同卵性FH (HoFH) 与从出生开始严重升高的LDL胆固醇.
- 低诊断和低治疗FH是重要的全球问题,突出需要提高认识和改善诊断可访问性.
研究的目的:
- 审查怀孕期间FH患者的复杂性和当前护理状况.
- 识别基于证据的指导方针中的差距,特别是怀孕和哺乳期间同卵同卵性FH (HoFH) 管理的差距.
主要方法:
- 文献综述专注于怀孕期间的FH管理.
- 分析当前的临床实践和现有指南.
主要成果:
- 目前还没有基于证据的指导方针,用于在怀孕计划,妊娠或哺乳期间管理HoFH.
- 怀孕期间的FH管理需要平衡母亲的LDL胆固醇降低与胎儿的福祉.
结论:
- 应考虑在怀孕期间和产后停止服用降脂药物;对于严重的HoFH,脂蛋白非也可能是一个选择.
- 涉及遗传咨询师,心脏病学家,脂质学家和产科医生的多学科护理至关重要.
- 进一步的研究,公众意识和全球合作对于改善怀孕期间的HoFH管理至关重要.
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