系统性免疫炎症指数作为慢性乙型肝炎与非酒精性脂肪肝疾病的预后标志物
Bo Xue1, Zeyu Wang2, Jianguo Li1
1Shanxi Medical University, Taiyuan, Shanxi Province, China.
Journal of infection in developing countries
|March 10, 2025
概括
高系统性免疫炎症指数 (SII) 是慢性乙型肝炎 (CHB) 和非酒精性脂肪肝疾病 (NAFLD) 患者肝硬化进展的重要危险因素. 升高的SII水平表明患肝硬化风险增加.
科学领域:
- 肝病学和免疫学 肝病学和免疫学
- 肝病的进展 肝病的进展
- 生物标志物发现发现
背景情况:
- 慢性乙型肝炎 (CHB) 和非酒精性脂肪肝 (NAFLD) 是导致肝病的主要原因.
- 肝硬化是这些疾病的严重并发症,需要早期检测和干预.
- 系统性免疫炎症指数 (SII) 是反映系统性炎症的潜在生物标志物.
研究的目的:
- 调查高系统性免疫炎症指数 (SII) 与肝硬化进展之间的关联.
- 确定SII是否可以预测CHB和NAFLD同时感染的患者的肝硬化发展.
- 评估SII在治疗NAFLD的CHB患者中的临床意义.
主要方法:
- 分析了272名患有CHB和NAFLD的患者队列.
- 接收器操作特征 (ROC) 曲线分析确定了1024的最佳SII切断值,用于预测肝硬化.
- 用单变量,多变量考克斯回归和卡普兰-梅尔分析来评估风险因素和生存结果.
主要成果:
- 单变量分析显示,SII是肝硬化进展的重要风险因素 (HR=2.062,p<0.001).
- 多变量分析证实,SII水平升高与肝硬化发病率增加独立相关 (HR=1.885,p=0.010).
- 卡普兰-梅尔分析表明,在60个月内高SII水平的患者中,肝硬化风险显著增加 (逻辑等级p<0.001).
结论:
- 系统性免疫炎症指数 (SII) 是NAFLD的CHB患者肝硬化发展的相关风险因素.
- 升高的SII水平与肝硬化进展的风险增加有关.
- 在临床管理中考虑SII可能会改善患者的治疗结果和风险分层.
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