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相关概念视频

Sequence Networks of Rotating Machines01:24

Sequence Networks of Rotating Machines

90
A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
90
Uniform Depth Channel Flow01:27

Uniform Depth Channel Flow

56
Uniform depth channel flow keeps fluid depth consistent along channels such as irrigation canals. In natural channels, such as rivers, approximate uniform flow is often assumed. This condition occurs when the channel’s bottom slope matches the energy slope, balancing potential energy lost from gravity with head loss due to shear stress. This balance prevents depth changes along the channel length, resulting in a steady, uniform flow.Uniform flow in open channels with a constant cross-section...
56
Uniform Depth Channel Flow: Problem Solving01:18

Uniform Depth Channel Flow: Problem Solving

48
To calculate the flow rate for a trapezoidal channel, first, identify the bottom width, side slope, and flow depth of the channel. The cross-sectional area (A) corresponding to the depth of flow (y), channel bottom width (B), and side slope (θ) is determined by:Next, calculate the wetted perimeter, which includes the bottom width and the sloped side lengths in contact with the water. Using the values of the cross-sectional area and the wetted perimeter, determine the hydraulic radius by...
48
Gradually Varying Flow01:29

Gradually Varying Flow

27
Gradually varying flow (GVF) in open channels describes situations where water depth changes slowly along the channel due to factors like non-uniform bed slope, channel shape variations, or obstructions. This flow type occurs when the depth adjusts gradually to balance gravitational forces, shear forces, and energy requirements, resulting in a low rate of depth change.Characteristics of Gradually Varying FlowGVF is commonly observed in natural streams, rivers, and canals, where flow depth...
27
Steady Flow of a Fluid Stream01:27

Steady Flow of a Fluid Stream

230
Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
230
Eulerian and Lagrangian Flow Descriptions01:22

Eulerian and Lagrangian Flow Descriptions

956
Fluid flow analysis is critical in many scientific and engineering disciplines, and two principal approaches are used to describe this flow: the Eulerian and Lagrangian methods. These methods offer different perspectives on monitoring and analyzing the motion of fluids, each with distinct advantages depending on the scenario.
The Eulerian method focuses on fixed points in space where fluid properties, such as velocity, pressure, and temperature, are observed as the fluid moves between these...
956

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相关实验视频

Updated: May 23, 2025

Ensemble Force Spectroscopy by Shear Forces
07:30

Ensemble Force Spectroscopy by Shear Forces

Published on: July 26, 2022

1.5K

P2DFlow:一种蛋白质组合生成模型,具有SE(3) 流量匹配.

Yaowei Jin1, Qi Huang2, Ziyang Song3

  • 1Lingang Laboratory, Shanghai 200031, China.

Journal of chemical theory and computation
|March 10, 2025
PubMed
概括

新的生成模型P2DFlow使用SE(3) 流匹配预测蛋白质结构组合. 这种方法准确地捕捉了蛋白质动态,有助于理解生物功能.

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Interactive Molecular Model Assembly with 3D Printing
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A Protocol for Computer-Based Protein Structure and Function Prediction
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相关实验视频

Last Updated: May 23, 2025

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07:30

Ensemble Force Spectroscopy by Shear Forces

Published on: July 26, 2022

1.5K
Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

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A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

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科学领域:

  • 计算生物学 计算生物学
  • 结构生物学 结构生物学
  • 生物物理学的生物物理.

背景情况:

  • 蛋白质的功能是由动态结构组合决定的,而不是单个构造.
  • 预测这些组合对于理解生物过程至关重要.

研究的目的:

  • 开发P2DFlow,一种用于预测蛋白质结构组合的生成模型.
  • 为了提高蛋白质动态的准确表示.

主要方法:

  • 使用SE(3) 流量匹配用于生成模型.
  • 整合了一个新的前期和一个组合数据的额外维度.
  • 在ATLAS的分子动力学 (MD) 数据上接受培训和评估.

主要成果:

  • 在预测蛋白质结构组合方面,P2DFlow的表现优于基线模型.
  • 成功捕获了在晶体结构和MD模拟中观察到的动态波动.
  • 生成高质量的合奏,反映了分布的物理规律.

结论:

  • P2DFlow 作为蛋白质分子模拟的潜在代理.
  • 该模型有助于理解不同生物场景中的蛋白质功能.
  • 高质量的整体预测可以促进结构生物学研究.